GREB1 and PALB2

Data Source:
BioGRID (two hybrid)

		GREB1	PALB2
Description		growth regulating estrogen receptor binding 1	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Membrane Extracellular Exosome	Nucleoplasm
	Molecular Function		DNA Binding Protein Binding
	Biological Process	Multicellular Organism Development	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways		Estrogen-dependent gene expression	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases			Fanconi anemia
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) Obesity-related traits ( 23251661) Uterine fibroids ( 30194396 31649266)	Bipolar disorder ( 17554300)
Interacting Genes		11 interacting genes: BCAR3 CASP8 CDKN2C HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3	32 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 H2BC3 H3C1 H4C1 HNRNPC IL13RA2 IL24 KEAP1 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		9687	79728
HPRD ID		13611	07966
Ensembl ID		ENSG00000196208	ENSG00000083093
Uniprot IDs		Q4ZG55	H3BN63 Q86YC2
PDB IDs			2W18 3EU7
Enriched GO Terms of Interacting Partners?
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