GREB1 and XRCC3

Data Source:
BioGRID (two hybrid)

		GREB1	XRCC3
Description		growth regulating estrogen receptor binding 1	X-ray repair cross complementing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Membrane Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm
	Molecular Function		Four-way Junction DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Multicellular Organism Development	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming
Pathways		Estrogen-dependent gene expression	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) Obesity-related traits ( 23251661) Uterine fibroids ( 30194396 31649266)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)
Interacting Genes		11 interacting genes: BCAR3 CASP8 CDKN2C HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3	22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7
Entrez ID		9687	7517
HPRD ID		13611	07201
Ensembl ID		ENSG00000196208	ENSG00000126215
Uniprot IDs		Q4ZG55	O43542 Q53XC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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