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SDC3 and LCE3D
Data Source:
BioGRID
(two hybrid)
SDC3
LCE3D
Description
syndecan 3
late cornified envelope 3D
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Golgi Lumen
Plasma Membrane
Cell Surface
Membrane
Integral Component Of Membrane
Lysosomal Lumen
Microspike
Collagen-containing Extracellular Matrix
Cytosol
Molecular Function
Protein Binding
Identical Protein Binding
Protein Binding
Biological Process
Retinoid Metabolic Process
Glycosaminoglycan Biosynthetic Process
Glycosaminoglycan Catabolic Process
Cell Migration
Leukocyte Migration
Cornification
Pathways
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Formation of the cornified envelope
Drugs
Diseases
GWAS
Loneliness (
27629369
)
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma (
31619474
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Psoriasis (
25854761
20953190
23143594
19169255
)
Interacting Genes
32 interacting genes:
AGR2
CASK
CMTM7
COL5A1
CSK
CTTN
CUX1
EPHB4
FGF2
FYN
ITGB4
KCNJ2
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP2-3
KRTAP2-4
KRTAP4-2
KRTAP5-7
KRTAP5-9
KRTAP9-2
LCE3D
MDK
PLN
PTN
SLC35A1
SMIM1
TMEM14C
TMEM218
TUBA1A
TUBB
TUBB2A
55 interacting genes:
ADAMTSL4
ALPP
CCN3
CHIC2
CYSRT1
EFEMP1
EFEMP2
FBLN2
KPRP
KRT31
KRTAP1-1
KRTAP1-3
KRTAP1-5
KRTAP10-1
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-3
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-1
KRTAP3-2
KRTAP3-3
KRTAP4-1
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-3
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE2B
LCE2C
MDFI
NBPF19
NOTCH2NLA
PCSK5
RGS17
RGS20
SDC3
SPRY1
SPRY3
SRPK1
SRPK2
TENM4
TGFB1
TRIM42
TSPAN4
VWC2
Entrez ID
9672
84648
HPRD ID
01719
17263
Ensembl ID
ENSG00000162512
ENSG00000163202
Uniprot IDs
O75056
Q9BYE3
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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