ISG15 and USP18

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ISG15	USP18
Description		ISG15 ubiquitin like modifier	ubiquitin specific peptidase 18
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Small Ribosomal Subunit	Nucleus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Integrin Binding Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Integrin-mediated Signaling Pathway Viral Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Translesion Synthesis Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Interferon-gamma Production Interleukin-10 Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Inflammatory Response Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling	ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)
Interacting Genes		6 interacting genes: HDAC6 HIF1A SQSTM1 UBA7 USP18 USP21	5 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 ZDHHC17
Entrez ID		9636	11274
HPRD ID		00958	06136
Ensembl ID		ENSG00000187608	ENSG00000184979
Uniprot IDs		P05161	Q9UMW8
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9
Enriched GO Terms of Interacting Partners?
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