ISG15 and UBA7

Data Source:
HPRD (two hybrid, in vivo)

		ISG15	UBA7
Description		ISG15 ubiquitin like modifier	ubiquitin like modifier activating enzyme 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Cytosolic Small Ribosomal Subunit	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Integrin Binding Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Activating Enzyme Activity
	Biological Process	Integrin-mediated Signaling Pathway Viral Process Protein Ubiquitination Modification-dependent Protein Catabolic Process Translesion Synthesis Positive Regulation Of Bone Mineralization Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Interferon-gamma Production Interleukin-10 Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway	Cellular Protein Modification Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Protein Modification By Small Protein Conjugation Negative Regulation Of Type I Interferon Production
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Interferon alpha/beta signaling Negative regulators of DDX58/IFIH1 signaling	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Menarche (age at onset) ( 25231870) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633)
Interacting Genes		6 interacting genes: HDAC6 HIF1A SQSTM1 UBA7 USP18 USP21	5 interacting genes: FAS ISG15 UBE2E1 UBE2L3 UBE2L6
Entrez ID		9636	7318
HPRD ID		00958	01873
Ensembl ID		ENSG00000187608	ENSG00000182179
Uniprot IDs		P05161	P41226
PDB IDs		1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL 5TL6 5W8T 5W8U 6BI8 6FFA 6XA9
Enriched GO Terms of Interacting Partners?
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