USP18 and TMEM14A

Data Source:
BioGRID (two hybrid)

		USP18	TMEM14A
Description		ubiquitin specific peptidase 18	transmembrane protein 14A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Inflammatory Response Regulation Of Type I Interferon-mediated Signaling Pathway	Mitochondrial Transport Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways		ISG15 antiviral mechanism Ub-specific processing proteases Regulation of IFNA signaling
Drugs
Diseases
GWAS			Metabolite levels ( 23823483) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Response to hepatitis B vaccine ( 29534301)
Interacting Genes		5 interacting genes: IFNAR2 ISG15 TMEM14A TRIM54 ZDHHC17	35 interacting genes: AQP6 CLN8 CPLX4 CREB3 CREB3L1 CXCR3 ERBB3 ERBB4 ERGIC3 ERMAP IER3IP1 KCNK5 LMNA LRCH1 LXN MMGT1 MTNR1A MTNR1B MUC1 NEMP1 PDZK1IP1 SCN3B SERINC2 SLC10A6 SLC18A1 SLC19A3 SLC7A1 SSMEM1 TMEM14B TMEM179B TMEM31 TMEM51 TMEM80 TMEM86B USP18
Entrez ID		11274	28978
HPRD ID		06136	15522
Ensembl ID		ENSG00000184979	ENSG00000096092
Uniprot IDs		Q9UMW8	Q9Y6G1
PDB IDs			2LOO 2LOP
Enriched GO Terms of Interacting Partners?
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