PRDX6 and CASP10

Data Source:
BioGRID (protein complementation assay)

		PRDX6	CASP10
Description		peroxiredoxin 6	caspase 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Glutathione Peroxidase Activity Phospholipase A2 Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Cadherin Binding 1-acylglycerophosphocholine O-acyltransferase Activity Calcium-independent Phospholipase A2 Activity Peroxiredoxin Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Neutrophil Degranulation Cell Redox Homeostasis Glycerophospholipid Catabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Cellular Oxidant Detoxification	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Detoxification of Reactive Oxygen Species Neutrophil degranulation	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs		2-(N-morpholino)ethanesulfonic acid Copper
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Adult body size ( 32376654) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Blood protein levels ( 30072576) Systemic lupus erythematosus ( 26663301) Systemic sclerosis ( 31672989)	Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		21 interacting genes: CASP10 CASP8 GPX4 GSTP1 HNF4G MAPK1 NCF2 NR4A1 ORM2 PAXIP1 PPARD PSMD8 RARA SFTPA1 STH SUMO2 SUMO4 TERF1 TERF2IP UCHL5 YWHAE	30 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP TNFRSF1A TRAF1 XIAP
Entrez ID		9588	843
HPRD ID		03817	03458
Ensembl ID		ENSG00000117592	ENSG00000003400
Uniprot IDs		P30041 V9HWC7	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		1PRX 5B6M 5B6N
Enriched GO Terms of Interacting Partners?
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