GTF2IRD1 and PKP1

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		GTF2IRD1	PKP1
Description		GTF2I repeat domain containing 1	plakophilin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Skin Epidermis Cadherin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Transition Between Slow And Fast Fiber	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways			Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs
Diseases			Ectodermal dysplasia/skin fragility syndrome
GWAS		Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)	Panic disorder ( 19165232) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5	16 interacting genes: BICDL2 CARD10 CEP76 DSC1 DSG1 DSP GOLGA2 GTF2IRD1 HOOK2 HSF2BP KRT14 KRT8 NFKBID TNS2 UCHL5 VIM
Entrez ID		9569	5317
HPRD ID		08379	03579
Ensembl ID		ENSG00000006704	ENSG00000081277
Uniprot IDs		E9PFE2 Q9UHL9	A0A024R952 Q13835
PDB IDs		2D99 2DN5 2DZQ 2DZR	1XM9
Enriched GO Terms of Interacting Partners?
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