GTF2IRD1 and COL15A1

Data Source:
BioGRID (genetic interference)

		GTF2IRD1	COL15A1
Description		GTF2I repeat domain containing 1	collagen type XV alpha 1 chain
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Extracellular Region Collagen Type XV Trimer Extracellular Space Endoplasmic Reticulum Lumen Integral Component Of Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Multicellular Organism Development Transition Between Slow And Fast Fiber	Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Signal Transduction Extracellular Matrix Organization Collagen Catabolic Process
Pathways			Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization
Drugs
Diseases
GWAS		Age at suicide ( 31476763) Aluminium levels ( 26025379) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Severe influenza A (H1N1) infection ( 26379185) SjÃ¶gren's syndrome ( 24097066) Systemic lupus erythematosus ( 26663301 28714469) Triglyceride levels ( 32203549)	Advanced age-related macular degeneration ( 26691988) Asthma ( 31959851 32296059) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 30804561) Epithelial ovarian cancer ( 25134534) Fractures (paediatric) ( 32742401) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Height ( 28552196) Lateral ventricle temporal horn volume ( 31530798) Pulse pressure ( 30224653 30578418)
Interacting Genes		24 interacting genes: ALMS1 ATP2C1 CDK20 DCAF6 EXOSC4 GORASP2 HDAC3 HTRA4 KPNA1 KPNA2 KPNA3 KPNA4 MRFAP1L1 PIAS1 PIAS2 PIP4P2 PKP1 PKP2 SELENOS SMAD3 SPTLC1 UBC USP20 ZMYM5
Entrez ID		9569	1306
HPRD ID		08379	00380
Ensembl ID		ENSG00000006704	ENSG00000204291
Uniprot IDs		E9PFE2 Q9UHL9	B3KTP7 P39059
PDB IDs		2D99 2DN5 2DZQ 2DZR	3N3F
Enriched GO Terms of Interacting Partners?
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