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PSMF1 and CTBP2
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PSMF1
CTBP2
Description
proteasome inhibitor subunit 1
C-terminal binding protein 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Endoplasmic Reticulum
Cytosol
Proteasome Core Complex
Membrane
Perinuclear Region Of Cytoplasm
Nucleus
Transcription Repressor Complex
Photoreceptor Ribbon Synapse
Presynaptic Active Zone Cytoplasmic Component
Glutamatergic Synapse
GABA-ergic Synapse
Presynaptic Cytosol
Molecular Function
Endopeptidase Inhibitor Activity
Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Proteasome Binding
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Kinase Binding
Retinoic Acid Receptor Binding
Protein-containing Complex Binding
NAD Binding
Structural Constituent Of Presynaptic Active Zone
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Synaptic Vesicle Docking
Viral Genome Replication
Positive Regulation Of Chromatin Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Maintenance Of Presynaptic Active Zone Structure
White Fat Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Repression of WNT target genes
Signaling by TCF7L2 mutants
Drugs
Diseases
GWAS
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Logical memory (immediate recall) in Alzheimer's disease dementia (
29274321
)
Adult body size (
32376654
)
Age-related cognitive decline (visuospatial skill) (slope of z-scores) (
30954325
)
Apolipoprotein A1 levels (
32203549
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Height (
25429064
)
Hemoglobin levels (
32327693
)
Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) (
30188897
)
Menarche (age at onset) (
25231870
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Prostate cancer (
18264096
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Vigorous physical activity (
29899525
)
Interacting Genes
36 interacting genes:
BEND7
CCDC85B
CD2BP2
CRX
CTBP2
DVL2
DVL3
GATA1
HOOK2
IKZF3
KHDRBS2
KHDRBS3
LDOC1
LNX1
LNX2
MAGEA11
MAGED1
MIEF2
NUDT21
PAK5
PDLIM7
PSMA7
QKI
RAB33A
RALYL
RBFOX1
RBFOX2
RBMX
RBPMS
RHOXF2
RNF126
TENT5B
TLE5
TRAF2
TRIM73
WWP2
99 interacting genes:
ACTG1
AKTIP
APP
BAZ2B
BCAS3
BCL3
C15orf39
CACNB1
CACNB2
CACNB3
CACNB4
CAPN7
CASP8AP2
CATSPER1
CBX4
CCDC120
CCNH
CCR5
CDKN2A
CEP68
CSTF2
CTBP1
CTPS2
DMRTB1
DTNB
DUSP21
DVL2
EEF1D
EGLN3
EIF4G1
ELAC2
ENKD1
EP300
FHL3
FLI1
FOXP2
FUNDC1
GLIS2
H3-4
HEMGN
HIC1
HOXA5
HOXB5
HOXC5
IKZF1
IKZF2
KCNIP3
KLF3
KLF8
KYNU
LCORL
LMO4
MDM2
MECOM
MSRB3
NEK6
NOL4
NOL4L
NRIP1
PLCB1
PNN
PPP1R15A
PROX1
PSMF1
QARS1
RAI2
RBBP8NL
RIMBP3
RNF135
RPL17
RPL7A
RPS28
RPS29
RPS4X
SDCBP
SHISA6
SOX13
SOX6
STUB1
STX11
TEAD3
TGIF1
TLE5
TRIML2
TSHZ3
UBC
UBE2I
VRTN
XRCC6
ZBP1
ZBTB18
ZBTB42
ZEB1
ZEB2
ZFPM1
ZFPM2
ZNF512B
ZNF750
ZSCAN4
Entrez ID
9491
1488
HPRD ID
17919
04016
Ensembl ID
ENSG00000125818
ENSG00000175029
Uniprot IDs
A0A140VJT2
B4DXW9
Q5QPM7
Q92530
P56545
PDB IDs
2VT8
4OUH
2OME
4LCJ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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