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CTBP2 and CCNH
Data Source:
BioGRID
(affinity chromatography technology, two hybrid)
CTBP2
CCNH
Description
C-terminal binding protein 2
cyclin H
Image
GO Annotations
Cellular Component
Nucleus
Transcription Repressor Complex
Photoreceptor Ribbon Synapse
Presynaptic Active Zone Cytoplasmic Component
Glutamatergic Synapse
GABA-ergic Synapse
Presynaptic Cytosol
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Molecular Function
RNA Polymerase II Transcription Corepressor Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
Protein Kinase Binding
Retinoic Acid Receptor Binding
Protein-containing Complex Binding
NAD Binding
Structural Constituent Of Presynaptic Active Zone
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell Population Proliferation
Synaptic Vesicle Docking
Viral Genome Replication
Positive Regulation Of Chromatin Binding
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Maintenance Of Presynaptic Active Zone Structure
White Fat Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Protein Stabilization
Phosphorylation Of RNA Polymerase II C-terminal Domain
Pathways
Repression of WNT target genes
Signaling by TCF7L2 mutants
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Age-related cognitive decline (visuospatial skill) (slope of z-scores) (
30954325
)
Apolipoprotein A1 levels (
32203549
)
Body mass index (
25673413
29273807
)
Body size at age 10 (
32376654
)
Brain morphology (MOSTest) (
32665545
)
Chronotype (
30696823
)
Diastolic blood pressure (
30224653
)
HDL cholesterol levels (
32203549
)
Height (
25429064
)
Hemoglobin levels (
32327693
)
Infant, child and juvenile death in continuous marriage (proportion of children died <15 years) (
30188897
)
Menarche (age at onset) (
25231870
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Prostate cancer (
18264096
)
Red blood cell count (
32888494
)
Refractive error (
32231278
)
Vigorous physical activity (
29899525
)
Adult body size (
32376654
)
Bipolar disorder lithium response (continuous) or schizophrenia (
29121268
)
Blood protein levels (
29875488
)
Diastolic blood pressure (
27841878
)
Initial pursuit acceleration (
29064472
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Prostate cancer aggressiveness (
25939597
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Interacting Genes
99 interacting genes:
ACTG1
AKTIP
APP
BAZ2B
BCAS3
BCL3
C15orf39
CACNB1
CACNB2
CACNB3
CACNB4
CAPN7
CASP8AP2
CATSPER1
CBX4
CCDC120
CCNH
CCR5
CDKN2A
CEP68
CSTF2
CTBP1
CTPS2
DMRTB1
DTNB
DUSP21
DVL2
EEF1D
EGLN3
EIF4G1
ELAC2
ENKD1
EP300
FHL3
FLI1
FOXP2
FUNDC1
GLIS2
H3-4
HEMGN
HIC1
HOXA5
HOXB5
HOXC5
IKZF1
IKZF2
KCNIP3
KLF3
KLF8
KYNU
LCORL
LMO4
MDM2
MECOM
MSRB3
NEK6
NOL4
NOL4L
NRIP1
PLCB1
PNN
PPP1R15A
PROX1
PSMF1
QARS1
RAI2
RBBP8NL
RIMBP3
RNF135
RPL17
RPL7A
RPS28
RPS29
RPS4X
SDCBP
SHISA6
SOX13
SOX6
STUB1
STX11
TEAD3
TGIF1
TLE5
TRIML2
TSHZ3
UBC
UBE2I
VRTN
XRCC6
ZBP1
ZBTB18
ZBTB42
ZEB1
ZEB2
ZFPM1
ZFPM2
ZNF512B
ZNF750
ZSCAN4
48 interacting genes:
AR
BLZF1
CALCOCO2
CCDC170
CCDC33
CCNC
CCT4
CDK2
CDK20
CDK3
CDK6
CDK7
CDK8
CSNK2B
CTBP2
DUSP12
ERCC3
ESR1
FUBP1
GANAB
GOLGA2
GRIPAP1
GTF2E2
GTF2H1
KLC3
MCM7
MCRS1
MTA1
MTMR7
NDC80
NEDD4
PICK1
POLR2A
POLR2B
PPFIA1
PSMA1
RARB
RHOH
SFN
SORBS3
SSX2IP
SUPT5H
TCF4
TP53
TRIM8
TRIML2
ZNF655
ZNRD2
Entrez ID
1488
902
HPRD ID
04016
09059
Ensembl ID
ENSG00000175029
ENSG00000134480
Uniprot IDs
P56545
P51946
PDB IDs
2OME
4LCJ
1JKW
1KXU
6O9L
6XBZ
6XD3
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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