SCARB1 and DENR

Data Source:
BioGRID (affinity chromatography technology)

		SCARB1	DENR
Description		scavenger receptor class B member 1	density regulated re-initiation and release factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Cellular_component
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Identical Protein Binding High-density Lipoprotein Particle Receptor Activity	Molecular_function MRNA Binding Translation Initiation Factor Activity Protein Binding
	Biological Process	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Receptor-mediated Endocytosis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Viral Entry Into Host Cell Regulation Of Phagocytosis Intestinal Absorption Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import	Formation Of Translation Preinitiation Complex Translation Reinitiation Ribosome Disassembly IRES-dependent Viral Translational Initiation
Pathways
Drugs		Phosphatidyl serine
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 29212778 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 31217584) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels (lipoprotein measures) ( 27005778) Monocyte percentage of white cells ( 32888494) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Total bilirubin levels ( 29403010) Total cholesterol levels ( 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881)	Apolipoprotein A1 levels ( 32203549) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355)
Interacting Genes		9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5	3 interacting genes: MCTS1 NELFB UBC
Entrez ID		949	8562
HPRD ID		03024	05182
Ensembl ID		ENSG00000073060	ENSG00000139726
Uniprot IDs		A0A024RBS4 Q8WTV0	A0A024RBR3 O43583
PDB IDs			5ONS 5VYC 6MS4 6VPQ 6VPR
Enriched GO Terms of Interacting Partners?
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