ROCK2 and CDKN3

Data Source:
BioGRID (affinity chromatography technology, pull down, imaging technique)

		ROCK2	CDKN3
Description		Rho associated coiled-coil containing protein kinase 2	cyclin dependent kinase inhibitor 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Protein Serine/threonine Kinase Activity Structural Molecule Activity Protein Binding ATP Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Rho-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Mitotic Cytokinesis Positive Regulation Of Protein Phosphorylation Response To Ischemia Aortic Valve Morphogenesis Protein Phosphorylation Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Rho Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Centrosome Duplication Negative Regulation Of Angiogenesis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Regulation Of Nervous System Process Positive Regulation Of Connective Tissue Growth Factor Production Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Myosin-light-chain-phosphatase Activity Viral RNA Genome Replication Regulation Of Circadian Rhythm Positive Regulation Of MAPK Cascade Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Rhythmic Process Embryonic Morphogenesis Regulation Of Protein Metabolic Process Centrosome Duplication Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly MRNA Destabilization Negative Regulation Of Biomineral Tissue Development Cellular Response To Testosterone Stimulus Response To Transforming Growth Factor Beta Protein Localization To Plasma Membrane Positive Regulation Of Fibroblast Growth Factor Production Blood Vessel Diameter Maintenance Regulation Of Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Regulation Of Cellular Response To Hypoxia Regulation Of Cell Junction Assembly Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly Cellular Response To Acetylcholine Positive Regulation Of Connective Tissue Replacement Response To Angiotensin Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Peptidyl-tyrosine Dephosphorylation
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse Sema4D induced cell migration and growth-cone collapse VEGFA-VEGFR2 Pathway RHO GTPases Activate ROCKs RHO GTPases Activate ROCKs RHOBTB1 GTPase cycle Potential therapeutics for SARS
Drugs		Fasudil Y-27632 Fostamatinib Ripasudil Netarsudil
Diseases
GWAS		LDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494)	Dental caries ( 23259602) Endometrial cancer (Non-endometrioid histology) ( 30093612) High myopia ( 31816047) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Monobrow thickness ( 26926045) Myopia ( 27182965) Refractive error ( 32231278) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		5 interacting genes: CDKN3 MAGEC1 PPP1R12A PTPRF STAU1	9 interacting genes: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3 PPP1R12A ROCK2
Entrez ID		9475	1033
HPRD ID		04922	00450
Ensembl ID		ENSG00000134318	ENSG00000100526
Uniprot IDs		A0A2P9DU05 O75116 Q14DU5	G3V2J7 Q16667
PDB IDs		4L6Q 4WOT 5U7Q 5U7R 6ED6 6P5M 6P5P 7JNT 7JOV	1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?
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