SH3BP5 and EXOC1

Data Source:
BioGRID (two hybrid)

		SH3BP5	EXOC1
Description		SH3 domain binding protein 5	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Nuclear Body Cytoplasmic Vesicle Membrane	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body Cytoplasmic Side Of Apical Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein Tyrosine Kinase Activity	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Viral Process Regulation Of Macroautophagy Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Defense Response To Virus
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439) Heschl's gyrus morphology ( 25130324) Prudent dietary pattern ( 28644415)	Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Urinary albumin excretion ( 32277301) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: APP BTK CDC5L DISC1 DST EXOC1 IFT20 MAPK10 MAPK12 MAPK8 MAPK9 NAP1L2 SOS1 SPTBN1 SYNE1 TNKS	30 interacting genes: ATG14 CCDC88A CCDC93 CCHCR1 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 NUP54 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SNAPIN SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIM9 TRIO
Entrez ID		9467	55763
HPRD ID		12030	07615
Ensembl ID		ENSG00000131370	ENSG00000090989
Uniprot IDs		A0A024R2J3 O60239	A0A024RDA1 A1LT29 Q9NV70
PDB IDs		4H3B 6DJL 6IXE 6IXF 6IXG 6IXV
Enriched GO Terms of Interacting Partners?
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