SH3BP5 and MAPK12

Data Source:
HPRD (in vitro)

		SH3BP5	MAPK12
Description		SH3 domain binding protein 5	mitogen-activated protein kinase 12
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Nuclear Body Cytoplasmic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding SH3 Domain Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein Tyrosine Kinase Activity	MAPK Cascade DNA Damage Induced Protein Phosphorylation Cell Cycle Arrest Signal Transduction Muscle Organ Development Positive Regulation Of Peptidase Activity Peptidyl-serine Phosphorylation Intracellular Signal Transduction Myoblast Differentiation Positive Regulation Of Muscle Cell Differentiation
Pathways			NOD1/2 Signaling Pathway p38MAPK events Activation of PPARGC1A (PGC-1alpha) by phosphorylation DSCAM interactions VEGFA-VEGFR2 Pathway Myogenesis Myogenesis Negative regulation of MAPK pathway
Drugs			Minocycline Phosphonothreonine Phosphoaminophosphonic Acid-Adenylate Ester KC706 CEP-1347
Diseases
GWAS		Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21956439) Heschl's gyrus morphology ( 25130324) Prudent dietary pattern ( 28644415)	Acne (severe) ( 24927181) Diverticular disease ( 30177863) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		16 interacting genes: APP BTK CDC5L DISC1 DST EXOC1 IFT20 MAPK10 MAPK12 MAPK8 MAPK9 NAP1L2 SOS1 SPTBN1 SYNE1 TNKS	29 interacting genes: DLG1 DLG2 DLG3 DLG4 DUSP1 EEF2K ERBIN GRB2 GTF2I HTRA2 MAP2K3 MAP2K4 MAP2K6 MAPKAPK5 MAPT MBP PATJ PDGFRL PKN1 PTPN3 PTPN4 RCSD1 RGS3 SH3BP5 SIAH1 SNTA1 SNTB1 SRPK1 TERF1
Entrez ID		9467	6300
HPRD ID		12030	03868
Ensembl ID		ENSG00000131370	ENSG00000188130
Uniprot IDs		A0A024R2J3 O60239	P53778 Q6N076
PDB IDs		4H3B 6DJL 6IXE 6IXF 6IXG 6IXV	1CM8 4QUM 6UNA
Enriched GO Terms of Interacting Partners?
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