CD33 and HERC3

Data Source:
BioGRID (two hybrid)

		CD33	HERC3
Description		CD33 molecule	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane	Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Ubiquitin-protein Transferase Activity
	Biological Process	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Neutrophil Degranulation Positive Regulation Of Protein Secretion Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Negative Regulation Of Monocyte Activation Positive Regulation Of Protein Tyrosine Phosphatase Activity	Protein Ubiquitination
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Gemtuzumab ozogamicin AVE9633
Diseases
GWAS		Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Basophil count ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) HIV-1 susceptibility ( 25786224) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triacylglyceride levels ( 31551469) White blood cell count ( 32888494 27863252)	Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		21 interacting genes: BMP10 C3orf52 CXCL9 CYB5B EMD GIMAP5 HERC3 KRT31 KRT35 KRT40 PTPN11 PTPN6 RPRM SCD SRC THSD7A TMBIM1 TMEM100 TMEM243 TNMD UBIAD1	13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
Entrez ID		945	8916
HPRD ID		01165	16093
Ensembl ID		ENSG00000105383	ENSG00000138641
Uniprot IDs		P20138 Q546G0	B4DK41 Q15034
PDB IDs		5IHB 5J06 5J0B 6D48 6D49 6D4A 6TL8
Enriched GO Terms of Interacting Partners?
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