HERC3 and HERC6

Data Source:
HPRD (in vivo)

		HERC3	HERC6
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle	Nucleoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity	Ubiquitin-protein Transferase Activity
	Biological Process	Protein Ubiquitination	Protein Polyubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Lean body mass ( 28552196) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	4 interacting genes: HERC3 HERC4 NME2 UBE2L3
Entrez ID		8916	55008
HPRD ID		16093	13647
Ensembl ID		ENSG00000138641	ENSG00000138642
Uniprot IDs		B4DK41 Q15034	Q8IVU3
PDB IDs			5W87
Enriched GO Terms of Interacting Partners?
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