HERC3 and CCL22

Data Source:
BioGRID (two hybrid)

		HERC3	CCL22
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	C-C motif chemokine ligand 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Ubiquitin-protein Transferase Activity	Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Protein Ubiquitination	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs
Diseases
GWAS		Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 32296059) Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469)
Interacting Genes		13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	10 interacting genes: AQP6 CCL14 CCL19 CCR4 CRYAB DPP4 GCLC HERC3 PF4V1 VCAM1
Entrez ID		8916	6367
HPRD ID		16093	04263
Ensembl ID		ENSG00000138641	ENSG00000102962
Uniprot IDs		B4DK41 Q15034	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?
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