TJP2 and CGN

Data Source:
HPRD (in vitro, in vivo)

		TJP2	CGN
Description		tight junction protein 2	cingulin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Cell-cell Contact Zone	Plasma Membrane Bicellular Tight Junction Myosin Complex Cell Junction
	Molecular Function	Guanylate Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding	Motor Activity Actin Binding Protein Binding Cadherin Binding
	Biological Process	Homotypic Cell-cell Adhesion Hippo Signaling Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability	Transforming Growth Factor Beta Receptor Signaling Pathway Biological_process
Pathways		Signaling by Hippo Apoptotic cleavage of cell adhesion proteins	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Drugs
Diseases
GWAS		Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)	Body mass index ( 26426971)
Interacting Genes		17 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 SRPK2 TJP1 YWHAB YWHAG YWHAZ	9 interacting genes: ARHGEF2 CDC42 F11R LNX1 PPP1R13B TJP1 TJP2 TP53BP2 YWHAG
Entrez ID		9414	57530
HPRD ID		06369	10827
Ensembl ID		ENSG00000119139	ENSG00000143375
Uniprot IDs		B7Z2R3 B7Z954 Q9UDY2	Q9P2M7
PDB IDs		2OSG 3E17
Enriched GO Terms of Interacting Partners?
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