OTOF and STK39

Data Source:
BioGRID (two hybrid)

		OTOF	STK39
Description		otoferlin	serine/threonine kinase 39
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cell Projection Presynaptic Active Zone Membrane	Nucleoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Calcium Ion Binding AP-2 Adaptor Complex Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Plasma Membrane Organization Sensory Perception Of Sound Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Membrane Fusion	Activation Of MAPK Activity Protein Phosphorylation Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs			Fostamatinib
Diseases		Deafness, autosomal recessive
GWAS		Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Periodontal microbiota ( 22699663)	Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		2 interacting genes: SRPK2 STK39	14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4
Entrez ID		9381	27347
HPRD ID		04727	09627
Ensembl ID		ENSG00000115155	ENSG00000198648
Uniprot IDs		Q9HC10	Q9UEW8
PDB IDs
Enriched GO Terms of Interacting Partners?
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