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AFDN and EPHB6
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vivo, in vitro)
AFDN
EPHB6
Description
afadin, adherens junction formation factor
EPH receptor B6
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Adherens Junction
Nuclear Speck
Cell Junction
Cell-cell Contact Zone
Pore Complex
Tight Junction
Extracellular Region
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Neuron Projection
Receptor Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
Small GTPase Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Ephrin Receptor Activity
Transmembrane-ephrin Receptor Activity
ATP Binding
Signaling Receptor Activity
Biological Process
Cell Adhesion
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Gene Expression
Positive Regulation Of Cell-cell Adhesion
Negative Regulation Of Cell Migration
Regulation Of Protein Localization
Adherens Junction Organization
Positive Regulation Of GTPase Activity
Cell-cell Adhesion Mediated By Cadherin
Pore Complex Assembly
Establishment Of Protein Localization To Plasma Membrane
Bicellular Tight Junction Assembly
Establishment Of Endothelial Intestinal Barrier
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Peptidyl-tyrosine Phosphorylation
Central Nervous System Projection Neuron Axonogenesis
Positive Regulation Of Kinase Activity
Ephrin Receptor Signaling Pathway
Pathways
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Drugs
(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Fostamatinib
Diseases
GWAS
Number of alcoholic drinks required to feel an effect (long-term average) (
31270906
)
Alcoholic chronic pancreatitis (
28754779
)
Blood protein levels (
30072576
29875488
)
Cancer (
29299148
)
Interacting Genes
37 interacting genes:
BCR
CTNNA1
EPHA7
EPHB2
EPHB3
EPHB6
F11R
HRAS
JAG1
LMO2
MRAS
NECTIN1
NECTIN2
NECTIN3
NECTIN4
NRXN1
NRXN2
NRXN3
PFN1
PICK1
RALGDS
RAP1A
RAP1GAP
RAP2A
RIN1
RIT1
RIT2
RRAS
RRAS2
SMAD2
SORBS1
SORBS2
SSX2IP
TJP1
USP9X
YWHAB
YWHAG
27 interacting genes:
AFDN
ASB12
CBL
CRK
CRKL
DDIT4L
DUSP18
DUSP19
EFNB2
EPHB1
ERBB2
GRB2
HDHD2
INCA1
MSX2
MTARC1
NIF3L1
NOTCH2NLA
POU6F2
PRMT5
REL
SAT1
STYX
TCF4
TEKT5
TRIB3
TRIM39
Entrez ID
4301
2051
HPRD ID
01164
04133
Ensembl ID
ENSG00000130396
ENSG00000106123
Uniprot IDs
A8MQ02
G1UI22
J3KN01
P55196
F8WCM8
J3KQU5
O15197
PDB IDs
1T2M
1XZ9
2AIN
2EXG
5A6C
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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