ARHGAP18 and BCS1L

Data Source:
BioGRID (affinity chromatography technology)

		ARHGAP18	BCS1L
Description		Rho GTPase activating protein 18	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Cadherin Binding	Protein Binding ATP Binding ATPase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly
Pathways		Rho GTPase cycle	Mitochondrial protein import
Drugs
Diseases			Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)	Male-pattern baldness ( 28196072)
Interacting Genes		2 interacting genes: MPHOSPH6 PALS2	3 interacting genes: DDX24 DNAJA1 MTDH
Entrez ID		93663	617
HPRD ID		12474	04708
Ensembl ID		ENSG00000146376	ENSG00000074582
Uniprot IDs		Q8N392	A0A024R445 A8JZZ8 Q9Y276
PDB IDs
Enriched GO Terms of Interacting Partners?
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