BCS1L and DNAJA1

Data Source:
BioGRID (two hybrid)

		BCS1L	DNAJA1
Description		BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone	DnaJ heat shock protein family (Hsp40) member A1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding
	Biological Process	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Flagellated Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		Mitochondrial protein import	HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs
Diseases		Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Male-pattern baldness ( 28196072)
Interacting Genes		3 interacting genes: DDX24 DNAJA1 MTDH	24 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LINC01554 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO2 SUMO4 TM4SF1 TXN
Entrez ID		617	3301
HPRD ID		04708	04159
Ensembl ID		ENSG00000074582	ENSG00000086061
Uniprot IDs		A0A024R445 A8JZZ8 Q9Y276	B7Z5C0 P31689
PDB IDs			2LO1 2M6Y 6E8M
Enriched GO Terms of Interacting Partners?
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