NREP and KMT2B

Data Source:
BioGRID (two hybrid)

		NREP	KMT2B
Description		neuronal regeneration related protein	lysine methyltransferase 2B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding
	Biological Process	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Regulation Of Neuron Differentiation	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation
Pathways			PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683) Gut microbiota relative abundance (Sutterella) ( 33208821) Hematocrit ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Reaction time ( 29844566) Red blood cell count ( 29403010 32888494) Thyroid cancer ( 28195142)	Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: ATM EEF1A1 EIF3B IGSF21 KMT2B	27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B
Entrez ID		9315	9757
HPRD ID		09545	06017
Ensembl ID		ENSG00000134986	ENSG00000272333
Uniprot IDs		Q16612	Q9UMN6
PDB IDs			3UVM 4ERZ 4PZI 7BRE
Enriched GO Terms of Interacting Partners?
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