KMT2B and RAP1B

Data Source:
BioGRID (two hybrid)

		KMT2B	RAP1B
Description		lysine methyltransferase 2B	RAP1B, member of RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation	Cell Population Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Cellular Response To Drug Interleukin-12-mediated Signaling Pathway Neutrophil Degranulation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Femoral neck bone mineral density ( 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) White blood cell count ( 20139978)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	30 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 MTUS2 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		9757	5908
HPRD ID		06017	01546
Ensembl ID		ENSG00000272333	ENSG00000127314
Uniprot IDs		Q9UMN6	A0A024RB87 B7ZAY2 P61224
PDB IDs		3UVM 4ERZ 4PZI 7BRE	3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6 6KYK 6OQ3 6OQ4
Enriched GO Terms of Interacting Partners?
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