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ACVR2B and WNT5A
Data Source:
BioGRID
(two hybrid)
ACVR2B
WNT5A
Description
activin A receptor type 2B
Wnt family member 5A
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Protein-containing Complex
Receptor Complex
Activin Receptor Complex
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Cell Surface
Clathrin-coated Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Postsynapse
Glutamatergic Synapse
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Activin Receptor Activity, Type II
Activin-activated Receptor Activity
Growth Factor Binding
Metal Ion Binding
Activin Binding
Frizzled Binding
Receptor Tyrosine Kinase-like Orphan Receptor Binding
Cytokine Activity
Protein Binding
Phospholipid Binding
Protein Domain Specific Binding
Receptor Ligand Activity
Chemoattractant Activity Involved In Axon Guidance
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Lymphangiogenesis
Blood Vessel Remodeling
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Signal Transduction
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anterior/posterior Pattern Specification
Positive Regulation Of Bone Mineralization
BMP Signaling Pathway
Activin Receptor Signaling Pathway
Positive Regulation Of Activin Receptor Signaling Pathway
Positive Regulation Of Osteoblast Differentiation
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Retina Vasculature Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cold-induced Thermogenesis
Activation Of MAPK Activity
Establishment Of Planar Polarity
Somitogenesis
Kidney Development
Epithelial To Mesenchymal Transition
Positive Regulation Of Endothelial Cell Proliferation
Heart Looping
Positive Regulation Of Mesenchymal Cell Proliferation
Lens Development In Camera-type Eye
Positive Regulation Of Cytokine Production Involved In Immune Response
Primary Heart Field Specification
Secondary Heart Field Specification
Atrial Septum Development
Type B Pancreatic Cell Development
Planar Cell Polarity Pathway Involved In Axis Elongation
Optic Cup Formation Involved In Camera-type Eye Development
Protein Phosphorylation
Wnt Signaling Pathway, Calcium Modulating Pathway
Activation Of JUN Kinase Activity
Axon Guidance
Hindgut Morphogenesis
Midgut Development
Male Gonad Development
Anterior/posterior Axis Specification, Embryo
Response To Organic Substance
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of T Cell Chemotaxis
Positive Regulation Of Neuron Projection Development
Wnt Signaling Pathway
Olfactory Bulb Interneuron Development
Neuron Differentiation
Keratinocyte Differentiation
Lung Development
Negative Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Binding
Activation Of Protein Kinase B Activity
Positive Regulation Of Chemokine Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Protein Localization
Non-canonical Wnt Signaling Pathway
Post-anal Tail Morphogenesis
Chemoattraction Of Serotonergic Neuron Axon
Chemorepulsion Of Dopaminergic Neuron Axon
Non-canonical Wnt Signaling Pathway Via JNK Cascade
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Wound Healing
Embryonic Digit Morphogenesis
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cell Fate Commitment
Establishment Of Epithelial Cell Apical/basal Polarity
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Angiogenesis
Positive Regulation Of Ossification
Positive Regulation Of Endocytosis
Positive Regulation Of Meiotic Nuclear Division
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Negative Regulation Of Melanin Biosynthetic Process
Positive Regulation Of Fibroblast Proliferation
Paraxial Mesoderm Formation
Notochord Morphogenesis
Embryonic Skeletal System Development
Genitalia Development
Negative Regulation Of Axon Extension Involved In Axon Guidance
Hypophysis Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Regulation Of Synapse Organization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cartilage Development
Positive Regulation Of Timing Of Anagen
Negative Regulation Of Synapse Assembly
Convergent Extension Involved In Axis Elongation
Convergent Extension Involved In Organogenesis
Uterus Development
Cervix Development
Vagina Development
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Urinary Bladder Development
Face Development
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis
Mesenchymal-epithelial Cell Signaling
Negative Regulation Of Prostatic Bud Formation
Mammary Gland Branching Involved In Thelarche
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of Response To Cytokine Stimulus
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation
Mesodermal To Mesenchymal Transition Involved In Gastrulation
Positive Regulation Of Macrophage Cytokine Production
Membrane Organization
Positive Regulation Of Cartilage Development
Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis
Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis
Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis
Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis
Secondary Palate Development
Positive Regulation Of Thymocyte Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Calcium Ion
Cellular Response To Retinoic Acid
Cellular Response To Interferon-gamma
Hematopoietic Stem Cell Proliferation
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Mesenchymal Cell Proliferation
Primitive Streak Formation
Positive Regulation Of Protein Kinase C Signaling
Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Activation Of GTPase Activity
Melanocyte Proliferation
Presynapse Assembly
Postsynapse Assembly
Regulation Of Postsynapse Organization
Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
Positive Regulation Of Neuron Projection Arborization
Positive Regulation Of Protein Kinase C Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Protein Localization To Synapse
Regulation Of Cellular Protein Localization
Excitatory Synapse Assembly
Inhibitory Synapse Assembly
Negative Regulation Of Cell Proliferation In Midbrain
Planar Cell Polarity Pathway Involved In Axon Guidance
Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Positive Regulation Of Non-canonical Wnt Signaling Pathway
Pathways
Signaling by NODAL
Regulation of signaling by NODAL
Signaling by Activin
Signaling by Activin
Signaling by BMP
TCF dependent signaling in response to WNT
TCF dependent signaling in response to WNT
WNT ligand biogenesis and trafficking
WNT ligand biogenesis and trafficking
Class B/2 (Secretin family receptors)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Ca2+ pathway
Ca2+ pathway
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
WNT5A-dependent internalization of FZD4
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
Heterotaxy; Situs ambiguus
GWAS
Bitter beverage consumption (
31046077
)
Body size at age 10 (
32376654
)
Estimated glomerular filtration rate (
31152163
31015462
)
P wave duration (
24850809
)
Carboplatin disposition in epthelial ovarian cancer (
29367611
)
Height (
28552196
)
Lung function (FEV1/FVC) (
28166213
)
Metabolite levels (
23823483
)
Type 2 diabetes (
30130595
)
Interacting Genes
21 interacting genes:
ACVR1B
BMP10
BMP2
BMP7
ERBIN
FBXO7
GDF11
GDF2
GDF5
IGSF1
INHBA
INHBB
INHBC
MSTN
NODAL
SNX1
SNX2
SNX6
SYNJ2BP
TDGF1
TGFBRAP1
3 interacting genes:
FZD1
FZD5
ROR2
Entrez ID
93
7474
HPRD ID
04106
01293
Ensembl ID
ENSG00000114739
ENSG00000114251
Uniprot IDs
Q13705
A0A024R316
A0A384N611
B3KQX9
P41221
PDB IDs
2H62
2QLU
4FAO
5NGV
5NHR
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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