WNT5A and ROR2

Data Source:
HPRD (in vitro)

		WNT5A	ROR2
Description		Wnt family member 5A	receptor tyrosine kinase like orphan receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Postsynapse Glutamatergic Synapse	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Frizzled Binding Receptor Tyrosine Kinase-like Orphan Receptor Binding Cytokine Activity Protein Binding Phospholipid Binding Protein Domain Specific Binding Receptor Ligand Activity Chemoattractant Activity Involved In Axon Guidance	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Activation Of MAPK Activity Establishment Of Planar Polarity Somitogenesis Kidney Development Epithelial To Mesenchymal Transition Positive Regulation Of Endothelial Cell Proliferation Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Cytokine Production Involved In Immune Response Primary Heart Field Specification Secondary Heart Field Specification Atrial Septum Development Type B Pancreatic Cell Development Planar Cell Polarity Pathway Involved In Axis Elongation Optic Cup Formation Involved In Camera-type Eye Development Protein Phosphorylation Wnt Signaling Pathway, Calcium Modulating Pathway Activation Of JUN Kinase Activity Axon Guidance Hindgut Morphogenesis Midgut Development Male Gonad Development Anterior/posterior Axis Specification, Embryo Response To Organic Substance Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of T Cell Chemotaxis Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Olfactory Bulb Interneuron Development Neuron Differentiation Keratinocyte Differentiation Lung Development Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Activation Of Protein Kinase B Activity Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Non-canonical Wnt Signaling Pathway Post-anal Tail Morphogenesis Chemoattraction Of Serotonergic Neuron Axon Chemorepulsion Of Dopaminergic Neuron Axon Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Wound Healing Embryonic Digit Morphogenesis Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Fate Commitment Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Angiogenesis Positive Regulation Of Ossification Positive Regulation Of Endocytosis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Melanin Biosynthetic Process Positive Regulation Of Fibroblast Proliferation Paraxial Mesoderm Formation Notochord Morphogenesis Embryonic Skeletal System Development Genitalia Development Negative Regulation Of Axon Extension Involved In Axon Guidance Hypophysis Morphogenesis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Synapse Organization Positive Regulation Of NF-kappaB Transcription Factor Activity Cartilage Development Positive Regulation Of Timing Of Anagen Negative Regulation Of Synapse Assembly Convergent Extension Involved In Axis Elongation Convergent Extension Involved In Organogenesis Uterus Development Cervix Development Vagina Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Urinary Bladder Development Face Development Positive Regulation Of Type I Interferon-mediated Signaling Pathway Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Mesenchymal-epithelial Cell Signaling Negative Regulation Of Prostatic Bud Formation Mammary Gland Branching Involved In Thelarche Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Response To Cytokine Stimulus Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Planar Cell Polarity Pathway Involved In Gastrula Mediolateral Intercalation Mesodermal To Mesenchymal Transition Involved In Gastrulation Positive Regulation Of Macrophage Cytokine Production Membrane Organization Positive Regulation Of Cartilage Development Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Secondary Palate Development Positive Regulation Of Thymocyte Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Retinoic Acid Cellular Response To Interferon-gamma Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Mesenchymal Cell Proliferation Primitive Streak Formation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Heart Induction By Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Activation Of GTPase Activity Melanocyte Proliferation Presynapse Assembly Postsynapse Assembly Regulation Of Postsynapse Organization Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Neuron Death Positive Regulation Of Protein Localization To Synapse Regulation Of Cellular Protein Localization Excitatory Synapse Assembly Inhibitory Synapse Assembly Negative Regulation Of Cell Proliferation In Midbrain Planar Cell Polarity Pathway Involved In Axon Guidance Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Planar Cell Polarity Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Non-canonical Wnt Signaling Pathway	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration
Pathways		TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Height ( 28552196) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Type 2 diabetes ( 30130595)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		3 interacting genes: FZD1 FZD5 ROR2	74 interacting genes: ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C19orf54 C1orf94 C3orf56 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MSX2 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34
Entrez ID		7474	4920
HPRD ID		01293	03822
Ensembl ID		ENSG00000114251	ENSG00000169071
Uniprot IDs		A0A024R316 A0A384N611 B3KQX9 P41221	Q01974
PDB IDs			3ZZW 4GT4 6OSH 6OSN 6OSV
Enriched GO Terms of Interacting Partners?
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