TNFAIP8 and PLEKHF1

Data Source:
BioGRID (two hybrid)

		TNFAIP8	PLEKHF1
Description		TNF alpha induced protein 8	pleckstrin homology and FYVE domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm	Nucleus Lysosome Lysosomal Membrane Endosome Endosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Apoptotic Process Endosome Organization Positive Regulation Of Autophagy Vesicle Organization Protein Localization To Plasma Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PI Metabolism
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Apolipoprotein A1 levels ( 32203549) Asthma ( 31361310 31959851 32296059 31619474) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heschl's gyrus morphology ( 25130324) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Multiple sclerosis ( 31604244) Plantar fascial disorders ( 29534260) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 28552196 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494)	Body mass index ( 26426971)
Interacting Genes		10 interacting genes: ATN1 EAF1 EAPP INO80E MED4 PLEKHF1 PLEKHF2 PRR13 SDCBP TIFA	7 interacting genes: CAVIN2 CHIC2 KIFBP L3MBTL3 NPM2 TNFAIP8 TNNT1
Entrez ID		25816	79156
HPRD ID		18204	15146
Ensembl ID		ENSG00000145779	ENSG00000166289
Uniprot IDs		B3KUI2 O95379	B4DWN9 Q96S99
PDB IDs
Enriched GO Terms of Interacting Partners?
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