TIMM50 and TNFRSF10B

Data Source:
BioGRID (two hybrid)

		TIMM50	TNFRSF10B
Description		translocase of inner mitochondrial membrane 50	TNF receptor superfamily member 10b
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Integral Component Of Membrane Nuclear Speck	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	RNA Binding Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Interleukin-2 Receptor Binding Protein Binding Ribonucleoprotein Complex Binding	Protein Binding Signaling Receptor Activity TRAIL Binding
	Biological Process	Release Of Cytochrome C From Mitochondria Protein Dephosphorylation Mitochondrial Membrane Organization Protein Import Into Mitochondrial Matrix Peptidyl-tyrosine Dephosphorylation	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Endoplasmic Reticulum Stress TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Leukocyte Migration Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Mitochondrial protein import	Caspase activation via Death Receptors in the presence of ligand Cell surface interactions at the vascular wall Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 TRAIL signaling
Drugs			HGS-TR2J Lexatumumab
Diseases
GWAS			Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Renal cell carcinoma ( 28598434)
Interacting Genes		5 interacting genes: DNM1 LY6E-DT PAFAH1B2 RAF1 TNFRSF10B	15 interacting genes: ASPH CASP8 CDC42 CFLAR FADD MADD MUC1 RIPK1 TIMM50 TMEM31 TNFRSF10A TNFRSF10D TNFSF10 TRADD ZDHHC15
Entrez ID		92609	8795
HPRD ID		12118	04680
Ensembl ID		ENSG00000105197	ENSG00000120889
Uniprot IDs		A0A024R0M6 Q3ZCQ8	O14763 Q7Z2I8
PDB IDs			1D0G 1D4V 1DU3 1ZA3 2H9G 3X3F 4I9X 4N90 4OD2 6NHW 6NHY 6T3J
Enriched GO Terms of Interacting Partners?
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