CD8B and ST3GAL4

Data Source:
HPRD (in vitro)

		CD8B	ST3GAL4
Description		CD8b molecule	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Early Endosome Membrane T Cell Receptor Complex	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Coreceptor Activity MHC Class I Protein Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Neolactotetraosylceramide Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity
	Biological Process	Adaptive Immune Response Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Positive Regulation Of Blood Coagulation Lipid Glycosylation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling Protein Sialylation
Pathways		Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Progressive supranuclear palsy ( 21685912)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)
Interacting Genes		3 interacting genes: CD3D CD8A ST3GAL4	2 interacting genes: ARHGDIA CD8B
Entrez ID		926	6484
HPRD ID		01725	00084
Ensembl ID		ENSG00000172116	ENSG00000110080
Uniprot IDs		P10966 Q53QL8	Q11206 Q6IBE6
PDB IDs
Enriched GO Terms of Interacting Partners?
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