ST3GAL4 and CD8B

Data Source:
HPRD (in vitro)

		ST3GAL4	CD8B
Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 4	CD8b molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Early Endosome Membrane T Cell Receptor Complex
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Neolactotetraosylceramide Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity	Protein Binding Coreceptor Activity MHC Class I Protein Binding
	Biological Process	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Positive Regulation Of Blood Coagulation Lipid Glycosylation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling Protein Sialylation	Adaptive Immune Response Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway T Cell Activation Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis	Nef Mediated CD8 Down-regulation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 32888494 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)	Progressive supranuclear palsy ( 21685912)
Interacting Genes		2 interacting genes: ARHGDIA CD8B	3 interacting genes: CD3D CD8A ST3GAL4
Entrez ID		6484	926
HPRD ID		00084	01725
Ensembl ID		ENSG00000110080	ENSG00000172116
Uniprot IDs		Q11206 Q6IBE6	P10966 Q53QL8
PDB IDs
Enriched GO Terms of Interacting Partners?
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