MAP3K13 and HLA-DRB3

Data Source:
BioGRID (two hybrid)

		MAP3K13	HLA-DRB3
Description		mitogen-activated protein kinase kinase kinase 13	major histocompatibility complex, class II, DR beta 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve	Adaptive Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation
Pathways			Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling
Drugs		Fostamatinib	1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)	Plantar warts ( 28928442)
Interacting Genes		8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25	4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC
Entrez ID		9175	3125
HPRD ID		05372	09985
Ensembl ID		ENSG00000073803
Uniprot IDs		O43283	A0A4D6G1L1 P79483
PDB IDs			2Q6W 3C5J 4H1L
Enriched GO Terms of Interacting Partners?
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