MAP3K13 and MAPK8IP1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		MAP3K13	MAPK8IP1
Description		mitogen-activated protein kinase kinase kinase 13	mitogen-activated protein kinase 8 interacting protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Membrane	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding IkappaB Kinase Complex Binding	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Neuron Maturation Peptidyl-serine Phosphorylation Positive Regulation Of Axon Extension Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Branching Morphogenesis Of A Nerve	Regulation Of Transcription, DNA-templated JUN Phosphorylation Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Positive Regulation Of JNK Cascade Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs		Fostamatinib	Pyrazolanthrone 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE 5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE Anthralin
Diseases
GWAS		Airflow obstruction ( 22837378) Arterial stiffness index ( 31235810) Major depressive disorder ( 27519822)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		8 interacting genes: GLO1 HLA-DRB3 IKBKB MAP2K7 MAPK8IP1 PRDX3 STAT3 TRIM25	26 interacting genes: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PARK7 PAX2 RECQL5 SNCA TIAM1 VRK2
Entrez ID		9175	9479
HPRD ID		05372	05223
Ensembl ID		ENSG00000073803	ENSG00000121653
Uniprot IDs		O43283	Q6NUQ9 Q9UQF2
PDB IDs			2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39 4HYS 4HYU 4IZY 5LW1 6FUZ
Enriched GO Terms of Interacting Partners?
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