HLA-DRB3 and CDCA8

Data Source:
BioGRID (two hybrid)

		HLA-DRB3	CDCA8
Description		major histocompatibility complex, class II, DR beta 3	cell division cycle associated 8
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Chromosome, Centromeric Region Nucleoplasm Nucleolus Cytosol Chromocenter Midbody Chromosome Passenger Complex Protein-containing Complex Intercellular Bridge Spindle Midzone
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding
	Biological Process	Adaptive Immune Response Myeloid Dendritic Cell Antigen Processing And Presentation Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Signal Transduction Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation	Mitotic Sister Chromatid Segregation Mitotic Metaphase Plate Congression Chromosome Organization Cell Division
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Plantar warts ( 28928442)	Axial length ( 24144296) Eyebrow thickness ( 26926045)
Interacting Genes		4 interacting genes: CDCA8 CTAG1B MAP3K13 POMC	26 interacting genes: AURKB BIRC5 EMILIN1 FBXO17 GYS1 H3C14 HLA-DRB3 HMBOX1 INCENP MAPKAPK5 NEK3 NKAPD1 NTAQ1 PIAS2 PIH1D2 RANBP2 RPRD1B SENP3 SET SGO1 SGO2 SNAPC5 SPANXN2 TTK UBE2I ZNF277
Entrez ID		3125	55143
HPRD ID		09985	13017
Ensembl ID			ENSG00000134690
Uniprot IDs		A0A4D6G1L1 P79483	Q53HL2
PDB IDs		2Q6W 3C5J 4H1L	2KDD 2QFA 2RAW 2RAX 6YIE 6YIF 6YIH
Enriched GO Terms of Interacting Partners?
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