NEXN and TRIM15

Data Source:
BioGRID (protein complementation assay)

		NEXN	TRIM15
Description		nexilin F-actin binding protein	tripartite motif containing 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Axon	Cytoplasm
	Molecular Function	Structural Constituent Of Muscle Actin Filament Binding Cell-cell Adhesion Mediator Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Regulation Of Cell Migration Regulation Of Cytoskeleton Organization Dendrite Self-avoidance	Mesodermal Cell Fate Determination Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell
Pathways
Drugs
Diseases
GWAS		FEV1 ( 30804560) Lung cancer in never smokers ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494)
Interacting Genes		11 interacting genes: ACTA1 CALM1 FAM107A FXR2 HMGB1 HMGB2 HSPB1 SIRPA TRIM15 ZNF250 ZSCAN22	39 interacting genes: ACD ACTB AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM YJU2
Entrez ID		91624	89870
HPRD ID		11388	15551
Ensembl ID		ENSG00000162614	ENSG00000204610
Uniprot IDs		B4DDI0 D3DQ79 Q0ZGT2	Q5SRL0 Q9C019
PDB IDs
Enriched GO Terms of Interacting Partners?
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