TRIM15 and CORO1B

Data Source:
BioGRID (protein complementation assay)

		TRIM15	CORO1B
Description		tripartite motif containing 15	coronin 1B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Stress Fiber Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Cell Leading Edge Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Cadherin Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Mesodermal Cell Fate Determination Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Actin Filament Organization Cell Migration Actin Cytoskeleton Organization Ruffle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Endothelial Cell Chemotaxis Cellular Response To Platelet-derived Growth Factor Stimulus Wound Healing Actin Filament Bundle Assembly Negative Regulation Of Smooth Muscle Cell Chemotaxis Actin Filament Branching Protein Localization To Cell Leading Edge Positive Regulation Of Lamellipodium Morphogenesis
Pathways
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494)	HDL cholesterol levels ( 32203549) Non-response to citalopram or escitalopram and depression ( 27622933) Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ACD ACTB AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM YJU2	8 interacting genes: ARPC2 KPNA2 LHX4 POLR1C PRKCA SSH1 TERF1 TRIM15
Entrez ID		89870	57175
HPRD ID		15551	16743
Ensembl ID		ENSG00000204610	ENSG00000172725
Uniprot IDs		Q5SRL0 Q9C019	A0A024R5K1 Q9BR76
PDB IDs
Enriched GO Terms of Interacting Partners?
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