TRIM15 and FBLIM1

Data Source:
BioGRID (protein complementation assay)

		TRIM15	FBLIM1
Description		tripartite motif containing 15	filamin binding LIM protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Fibrillar Center Stress Fiber Cytoplasm Cytosol Focal Adhesion Cell Junction Cell Periphery
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Filamin Binding Metal Ion Binding
	Biological Process	Mesodermal Cell Fate Determination Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell	Regulation Of Cell Shape Regulation Of Integrin Activation Cell Junction Assembly Cell-cell Adhesion
Pathways			Cell-extracellular matrix interactions
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494) Neurociticism ( 29500382) Neuroticism ( 29255261) Red cell distribution width ( 32888494)	Alcoholic chronic pancreatitis ( 28754779) Cardiac Troponin-T levels ( 23247143) Gut microbiota (bacterial taxa) ( 27723756) Heel bone mineral density ( 30598549)
Interacting Genes		39 interacting genes: ACD ACTB AXIN1 CDK6 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FAM161B FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM YJU2	11 interacting genes: ADAT3 C19orf54 CUTA FERMT2 FLNA FLNB H3-5 H3C1 LMO3 SHISA6 TRIM15
Entrez ID		89870	54751
HPRD ID		15551	09669
Ensembl ID		ENSG00000204610	ENSG00000162458
Uniprot IDs		Q5SRL0 Q9C019	Q8WUP2
PDB IDs			2K9U 2W0P 4P3W
Enriched GO Terms of Interacting Partners?
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