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EXO1 and YWHAB
Data Source:
BioGRID
(two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology)
EXO1
YWHAB
Description
exonuclease 1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Nuclear Body
Nucleus
Cytoplasm
Mitochondrion
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
DNA Binding
Chromatin Binding
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
5'-flap Endonuclease Activity
5'-3' Exodeoxyribonuclease Activity
Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Metal Ion Binding
Flap Endonuclease Activity
Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Protein Kinase Inhibitor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Biological Process
Humoral Immune Response Mediated By Circulating Immunoglobulin
DNA Replication
DNA Repair
Mismatch Repair
DNA Recombination
Somatic Hypermutation Of Immunoglobulin Genes
Isotype Switching
Meiotic Cell Cycle
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
T-circle Formation
Regulation Of Signal Transduction By P53 Class Mediator
MAPK Cascade
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Viral Process
Negative Regulation Of Protein Dephosphorylation
Hippo Signaling
Positive Regulation Of Catalytic Activity
Regulation Of MRNA Stability
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Cytoplasmic Sequestering Of Protein
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Basal cell carcinoma (
31174203
)
Breast cancer (
25751625
29059683
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Keratinocyte cancer (MTAG) (
31174203
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Menopause (age at onset) (
22267201
26414677
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Interacting Genes
19 interacting genes:
ATM
BLM
DCAF1
KPNA4
KPNB1
MLH1
MSH2
MSH3
PCNA
PMS2
SENP6
SFN
UBE2I
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
142 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
Entrez ID
9156
7529
HPRD ID
06932
03184
Ensembl ID
ENSG00000174371
ENSG00000166913
Uniprot IDs
A8K5H6
Q9UQ84
P31946
V9HWD6
PDB IDs
3QE9
3QEA
3QEB
5UZV
5V04
5V05
5V06
5V07
5V08
5V09
5V0A
5V0B
5V0C
5V0D
5V0E
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
Enriched GO Terms of Interacting Partners
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