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EXO1
Description
exonuclease 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Nuclear Body
Molecular Function
DNA Binding
Chromatin Binding
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Protein Binding
5'-3' Exonuclease Activity
5'-flap Endonuclease Activity
5'-3' Exodeoxyribonuclease Activity
Single-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Metal Ion Binding
Flap Endonuclease Activity
Double-stranded DNA 5'-3' Exodeoxyribonuclease Activity
Biological Process
Humoral Immune Response Mediated By Circulating Immunoglobulin
DNA Replication
DNA Repair
Mismatch Repair
DNA Recombination
Somatic Hypermutation Of Immunoglobulin Genes
Isotype Switching
Meiotic Cell Cycle
RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
T-circle Formation
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Basal cell carcinoma (
31174203
)
Breast cancer (
25751625
29059683
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Keratinocyte cancer (MTAG) (
31174203
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Menopause (age at onset) (
22267201
26414677
)
Interacting Genes
19 interacting genes:
ATM
BLM
DCAF1
KPNA4
KPNB1
MLH1
MSH2
MSH3
PCNA
PMS2
SENP6
SFN
UBE2I
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
9156
HPRD ID
06932
Ensembl ID
ENSG00000174371
Uniprot IDs
A8K5H6
Q9UQ84
PDB IDs
3QE9
3QEA
3QEB
5UZV
5V04
5V05
5V06
5V07
5V08
5V09
5V0A
5V0B
5V0C
5V0D
5V0E
Enriched GO Terms of Interacting Partners
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