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YWHAB and PARD6B
Data Source:
HPRD
(in vivo)
YWHAB
PARD6B
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
par-6 family cell polarity regulator beta
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Vacuolar Membrane
Cytosol
Focal Adhesion
Membrane
Transcription Repressor Complex
Melanosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Cytosol
Plasma Membrane
Bicellular Tight Junction
Cell Cortex
Apical Plasma Membrane
Protein-containing Complex
Extracellular Exosome
Molecular Function
Protein Kinase Inhibitor Activity
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Deacetylase Binding
Protein-containing Complex Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Kinase C Binding
Protein Binding
Biological Process
MAPK Cascade
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Viral Process
Negative Regulation Of Protein Dephosphorylation
Hippo Signaling
Positive Regulation Of Catalytic Activity
Regulation Of MRNA Stability
Negative Regulation Of G Protein-coupled Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Cytoplasmic Sequestering Of Protein
Membrane Organization
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cell-cell Junction Assembly
Centrosome Cycle
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Regulation Of Cell Migration
Cell Division
Regulation Of Cellular Localization
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
MTOR signalling
mTORC1-mediated signalling
Frs2-mediated activation
Frs2-mediated activation
ARMS-mediated activation
Signaling by Hippo
Rap1 signalling
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
RAF activation
MAP2K and MAPK activation
Negative regulation of MAPK pathway
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Signaling by MRAS-complex mutants
Tight junction interactions
Drugs
Copper
Phenethyl Isothiocyanate
Diseases
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Breakfast cereal skipping frequency (
31190057
)
Breakfast skipping (
31190057
)
Mean platelet volume (
32888494
)
Bipolar disorder (
21771265
)
Interacting Genes
142 interacting genes:
ABL1
ADAM22
AFDN
AKAP13
ALS2
APP
ATP5F1A
BAD
BAX
BCL2L11
BCR
BID
BRAF
C1QBP
CAMK2A
CAMK2B
CBL
CDC25A
CDC25B
CDC25C
CDK11B
CDK14
CDKN1B
CHAF1A
CRTC2
CSNK2A1
DAPK1
DHX15
DYRK1A
EDC3
EGFR
EPB41
EPB41L1
EPB41L3
ERRFI1
EXO1
FER
FRMD6
GAPVD1
GEM
H3C1
HDAC5
HES1
HSP90AB1
HSPA1A
HSPA1B
HSPA5
HSPB1
IGF1R
IKBKB
ING1
INSR
IRS1
IRS2
ITGB1
ITGB4
KANK1
KCNK15
KCNK3
KCNK9
KIAA0930
KIF1C
KIF23
KIF5B
KLC1
KRT18
LARP1
LYST
MAP3K3
MAPK7
MAPT
MARK2
MARK4
MDM4
MICALL1
MINK1
MLXIP
MPRIP
MST1R
MTNR1A
MTNR1B
OSBPL3
PARD3
PARD6B
PDCL2
PDE3B
PI4KB
PIK3R2
PIK3R4
PRKCD
PRKCG
PRKCZ
PRPF6
PTPN3
RABGEF1
RACGAP1
RADIL
RAF1
RAI14
RALGPS2
RASGRF1
RGS3
RGS7
RIN1
RIOK1
RMDN3
RNPS1
RPS6KA1
SAMSN1
SKP2
SLC4A7
SLC8A1
SLC8A2
SLC8A3
SLC9A1
SNCA
SNRNP200
SON
SRC
SRRM2
SRSF10
SRSF3
STK38
STK38L
TESK1
TESK2
TH
TJP2
TNFAIP3
TPD52L1
TSC1
TSC2
TUBB
UBC
UCP2
UCP3
WDR77
WEE1
YWHAE
YWHAG
ZFP36
ZFP36L1
33 interacting genes:
APP
ARAP3
BANP
CDC42
CDCA4
CEP76
FRMD6
GMCL1
GOLGA2
HSF2BP
HTRA1
MAGOHB
PALS1
PARD3
PARD3B
PARD6A
PNMA1
PRKCG
PRKCI
PRKCZ
RAC1
RASSF3
RHOJ
RHOQ
SIAH1
TCP10L3
TRIB3
TRIM35
WDR83
YWHAB
YWHAH
YWHAZ
ZSCAN4
Entrez ID
7529
84612
HPRD ID
03184
18703
Ensembl ID
ENSG00000166913
ENSG00000124171
Uniprot IDs
P31946
V9HWD6
Q9BYG5
PDB IDs
2BQ0
2C23
4DNK
5N10
6A5Q
6BYK
6GN0
6GN8
6GNJ
6GNK
6GNN
6HEP
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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