PRPF3 and RBM39

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF3	RBM39
Description		pre-mRNA processing factor 3	RNA binding motif protein 39
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Nucleoplasm Microtubule Cytoskeleton Nuclear Speck Protein-containing Complex Centriolar Satellite
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Binding Protein Binding RS Domain Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	RNA Processing MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Ambidextrousness ( 32989287) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Blood protein levels ( 28240269) Refractive error ( 32231278)
Interacting Genes		52 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RBM39 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA U2AF2 USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT ZRANB1	60 interacting genes: AK8 APP ARL6IP4 BANP CDC42 CHERP CLK1 CLK2 CSNK2A1 CSNK2B DARS1-AS1 DDX39B DVL3 ESR1 ESR2 FAM200A GOLGA2 H1-2 HNRNPH2 HOMEZ HSPB1 INO80B JUN KHDC4 KRTAP12-2 MCPH1 MLX MTNR1A NCOA6 NKAP NKAPD1 PGR PHC2 POU6F2 PPIG PRPF3 PRPF38A PRPF40A RBM23 RBM25 REL RNF113A RP9P SAP18 SAP30BP SDCBP SF3B4 SP100 SREK1 SREK1IP1 SRPK1 SRPK2 SRRM4 SRSF11 THAP1 TOE1 TTC14 U2AF2 ZBTB22 ZCCHC10
Entrez ID		9129	9584
HPRD ID		07389	09201
Ensembl ID		ENSG00000117360	ENSG00000131051
Uniprot IDs		O43395	A0A384NQ03 B4DRA0 E1P5S2 Q14498 Q6N037
PDB IDs		1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	2JRS 2MHN 4OO6 4OZ0 4OZ1 4YUD 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5
Enriched GO Terms of Interacting Partners?
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