PRPF3 and SNRNP200

Data Source:
BioGRID (two hybrid)

		PRPF3	SNRNP200
Description		pre-mRNA processing factor 3	small nuclear ribonucleoprotein U5 subunit 200
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U5 SnRNP Membrane U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Cis Assembly Of Pre-catalytic Spliceosome Spliceosome Conformational Change To Release U4 (or U4atac) And U1 (or U11) MRNA Splicing, Via Spliceosome Osteoblast Differentiation
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)	Retinitis pigmentosa (RP)
GWAS		Ambidextrousness ( 32989287) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Interacting Genes		52 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RBM39 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA U2AF2 USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT ZRANB1	34 interacting genes: APC BARD1 BCAS2 BRCA1 CHMP1B DHX38 DUX4 ECT2 EFTUD2 ERG GNMT GRB2 HNRNPA1 HSPB1 LSM8 MATR3 MEGF10 PIN1 PRPF3 PRPF31 PRPF8 PTEN RNF113A SF3B2 SF3B3 SMNDC1 SNRNP40 SNW1 SUMO2 UBE2I USP19 WBP4 YWHAB YWHAG
Entrez ID		9129	23020
HPRD ID		07389	03391
Ensembl ID		ENSG00000117360	ENSG00000144028
Uniprot IDs		O43395	O75643
PDB IDs		1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	2Q0Z 3JCR 4F91 4F92 4F93 4KIT 5O9Z 5URJ 5URK 5URM 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6FF7 6ICZ 6QDV 6QW6 6QX9 6S8O 6S8Q 6S9I 7A5P
Enriched GO Terms of Interacting Partners?
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