SLC16A3 and HDAC7

Data Source:
BioGRID (two hybrid)

		SLC16A3	HDAC7
Description		solute carrier family 16 member 3	histone deacetylase 7
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Nuclear Membrane Parallel Fiber To Purkinje Cell Synapse Integral Component Of Postsynaptic Density Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Symporter Activity	Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding
	Biological Process	Pyruvate Metabolic Process Monocarboxylic Acid Transport Plasma Membrane Lactate Transport Leukocyte Migration	Protein Deacetylation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Basigin interactions Proton-coupled monocarboxylate transport Pyruvate metabolism	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Pyruvic acid	Trichostatin A Belinostat Panobinostat
Diseases
GWAS		Hemoglobin ( 32888494) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738 32296059) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BANP BSG CDC42 FAM9B GJA8 HDAC7 HPCA NR2C2AP UBQLN1 UBQLN2	59 interacting genes: ACOT11 ACTN4 ANTKMT ARID5A BCL6 BRWD1 C3orf36 CALCOCO2 CASP8 CDC42 CENPQ DDIT4L EDNRA EGFR ESM1 GNG12 GNMT GOLGA6L9 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 KLF16 KRBA2 LDB2 MARK2 MARK3 MEF2A MEF2C MEOX2 MIEN1 NCOR2 NME4 NRIP2 PATJ PHC2 PPARD PPP1R16A PRKD1 PRKD2 RAC1 RAC2 RAC3 REL RIPPLY1 RRAS2 RUNX2 SIN3A SLC16A3 SOGA1 TIAF1 UBE2I UBL3 YPEL3 YWHAG YWHAQ ZBTB16
Entrez ID		9123	51564
HPRD ID		04854	09133
Ensembl ID		ENSG00000141526	ENSG00000061273
Uniprot IDs		A0A024R8U1 O15427	Q8WUI4
PDB IDs			3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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