STARD13 and HMGCR

Data Source:
HPRD (in vivo, two hybrid)

		STARD13	HMGCR
Description		StAR related lipid transfer domain containing 13	3-hydroxy-3-methylglutaryl-CoA reductase
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GO Annotations	Cellular Component	Lipid Droplet Cytosol Mitochondrial Membrane	Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding	Hydroxymethylglutaryl-CoA Reductase (NADPH) Activity Protein Binding Hydroxymethylglutaryl-CoA Reductase Activity NADPH Binding Coenzyme A Binding
	Biological Process	Signal Transduction Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Endothelial Cell Migration Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Endothelial Tube Lumen Extension	Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Coenzyme A Metabolic Process Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Protein Secretion Negative Regulation Of Amyloid-beta Clearance
Pathways		Rho GTPase cycle	EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			NADH Pravastatin Lovastatin Cerivastatin Simvastatin Atorvastatin Fluvastatin Rosuvastatin Coenzyme A (S)-Hmg-Coa Nicotinamide adenine dinucleotide phosphate Meglutol 1,4-Dithiothreitol TAK-475 Mevastatin Pitavastatin Cannabidiol Medical Cannabis Nabiximols
Diseases
GWAS		Body mass index in asthmatics ( 23517042) Colorectal cancer or advanced adenoma ( 30510241) Diverticular disease ( 30177863) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Intracranial aneurysm ( 20364137) Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494)	Apolipoprotein B levels ( 32203549) Body mass index ( 20935630) Cholesterol ( 31902109) Cholesterol, total ( 24097068 28270201 19060911 25961943 20686565 26582766) Coronary artery disease ( 33020668) LDL cholesterol ( 24097068 18802019 18193044 20864672 19060906 19060911 25961943 20686565 26582766) LDL cholesterol levels ( 32203549 28334899 31087446) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 32154731 29403010) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 21909109 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Quantitative traits ( 19197348) Total cholesterol levels ( 28334899 31087446 30275531) Type 2 diabetes ( 32499647)
Interacting Genes		12 interacting genes: ADGRB2 EPB41L1 HMGCR HSP90AA1 HSP90AB1 ITPR1 KIF1B SMAD1 SMARCD3 TAX1BP1 TUBA1A TUBA4A	4 interacting genes: ARHGAP1 INSIG1 PRKACA STARD13
Entrez ID		90627	3156
HPRD ID		11607	00836
Ensembl ID		ENSG00000133121	ENSG00000113161
Uniprot IDs		A0A024RDV4 B2R789 B3KRK6 Q9Y3M8	A0A024RAP2 P04035
PDB IDs		2H80 2JW2 2PSO	1DQ8 1DQ9 1DQA 1HW8 1HW9 1HWI 1HWJ 1HWK 1HWL 2Q1L 2Q6B 2Q6C 2R4F 3BGL 3CCT 3CCW 3CCZ 3CD0 3CD5 3CD7 3CDA 3CDB
Enriched GO Terms of Interacting Partners?
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