EXOC3L2 and TNFSF18

Data Source:
BioGRID (two hybrid)

		EXOC3L2	TNFSF18
Description		exocyst complex component 3 like 2	TNF superfamily member 18
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cellular_component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	SNARE Binding Molecular_function Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding
	Biological Process	Exocytosis Biological_process Exocyst Localization	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Positive Regulation Of Leukocyte Migration Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis
Pathways			TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Mean platelet volume ( 32888494 27863252) Parental longevity (father's attained age) ( 29227965) Platelet count ( 22139419 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 29559957) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 27182965) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		6 interacting genes: BIK GAGE12G GAGE2E GPR148 MRPL12 TNFSF18	2 interacting genes: EXOC3L2 TNFRSF18
Entrez ID		90332	8995
HPRD ID		10311	04874
Ensembl ID		ENSG00000283632	ENSG00000120337
Uniprot IDs		Q2M3D2	A0A0U5JXL4 Q9UNG2
PDB IDs			2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?
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