TNFSF18 and EXOC3L2

Data Source:
BioGRID (two hybrid)

		TNFSF18	EXOC3L2
Description		TNF superfamily member 18	exocyst complex component 3 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Exocyst Cellular_component
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	SNARE Binding Molecular_function Protein Binding
	Biological Process	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Positive Regulation Of Leukocyte Migration Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis	Exocytosis Biological_process Exocyst Localization
Pathways		TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 27182965) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)	Advanced age-related macular degeneration ( 26691988) Alzheimer's disease ( 24755620) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Mean platelet volume ( 32888494 27863252) Parental longevity (father's attained age) ( 29227965) Platelet count ( 22139419 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494) Serum uric acid levels ( 29559957) White blood cell count ( 32888494)
Interacting Genes		2 interacting genes: EXOC3L2 TNFRSF18	6 interacting genes: BIK GAGE12G GAGE2E GPR148 MRPL12 TNFSF18
Entrez ID		8995	90332
HPRD ID		04874	10311
Ensembl ID		ENSG00000120337	ENSG00000283632
Uniprot IDs		A0A0U5JXL4 Q9UNG2	Q2M3D2
PDB IDs		2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?
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