TNFSF18 and TNFRSF18

Data Source:
HPRD (in vivo)

		TNFSF18	TNFRSF18
Description		TNF superfamily member 18	TNF receptor superfamily member 18
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding	Tumor Necrosis Factor-activated Receptor Activity Protein Binding
	Biological Process	Adaptive Immune Response T Cell Proliferation Involved In Immune Response Positive Regulation Of Leukocyte Migration Signal Transduction Cell-cell Signaling Positive Regulation Of Macrophage Chemotaxis Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Adhesion Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Dendritic Cell Chemotaxis	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Alopecia areata ( 25608926) Asthma ( 30929738 27182965) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Celiac disease ( 22057235 20190752 24999842) Crohn's disease ( 21102463 23128233) Itch intensity from mosquito bite ( 28199695) Pediatric autoimmune diseases ( 26301688)	Inflammatory bowel disease ( 23128233)
Interacting Genes		2 interacting genes: EXOC3L2 TNFRSF18	6 interacting genes: LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2
Entrez ID		8995	8784
HPRD ID		04874	04879
Ensembl ID		ENSG00000120337	ENSG00000186891
Uniprot IDs		A0A0U5JXL4 Q9UNG2	A0A0R7FDM1 Q9Y5U5
PDB IDs		2Q1M 2R30 2R32 3B93 3B94
Enriched GO Terms of Interacting Partners?
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