TAF1C and POLR1E

Data Source:
HPRD (in vitro)

		TAF1C	POLR1E
Description		TATA-box binding protein associated factor, RNA polymerase I subunit C	RNA polymerase I subunit E
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus	Fibrillar Center Nucleoplasm Nucleolus RNA Polymerase I Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Protein Binding	RNA Polymerase I General Transcription Initiation Factor Binding DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Positive Regulation Of Gene Expression, Epigenetic	RNA Polymerase I Preinitiation Complex Assembly Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic
Pathways		SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Autism ( 22843504) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		13 interacting genes: H2AX POLR1E RRN3 SMN1 TAF1A TAF1B TBP TK1 TP53 TRIM24 TTR UBTF UFD1	8 interacting genes: NFKBIB POLR1A POLR1B POLR1C POLR1G SIRT7 TAF1C UBTF
Entrez ID		9013	64425
HPRD ID		05364	15096
Ensembl ID		ENSG00000103168	ENSG00000137054
Uniprot IDs		B3KUE8 Q15572	B4E005 Q9GZS1
PDB IDs
Enriched GO Terms of Interacting Partners?
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