TSR2 and RPS26

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSR2	RPS26
Description		TSR2 ribosome maturation factor	ribosomal protein S26
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytosol Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Polysomal Ribosome Extracellular Exosome Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	RNA Binding MRNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding
	Biological Process	Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Negative Regulation Of RNA Splicing
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		Prostate cancer ( 31562322)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Asthma ( 31959851 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive function ( 25644384) Hypothyroidism ( 27182965) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Nonsyndromic cleft lip with cleft palate ( 28232668) Psoriasis ( 20953189 25574825) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		24 interacting genes: CAMK2A CMIP CREB5 DAPL1 DISC1 EXOSC3 GABARAP GABARAPL2 GAS2L3 GSC2 KIF16B KIFC3 LAMB2 MAP1LC3C MEOX2 PIAS2 PRKAB2 PTRHD1 RBM48 RPS26 SPATC1L ZBTB9 ZNF474 ZNF620	7 interacting genes: APP NDRG1 OTX2 PTEN SDCBP SRPK2 TSR2
Entrez ID		90121	6231
HPRD ID		06493	04743
Ensembl ID		ENSG00000158526	ENSG00000197728
Uniprot IDs		A0A024R9U9 Q969E8	A0A024RB14 P62854
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6G5H 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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