LIMD1 and STAC

Data Source:
BioGRID (two hybrid)

		LIMD1	STAC
Description		LIM domain containing 1	SH3 and cysteine rich domain
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Adherens Junction Focal Adhesion RISC Complex	Cytosol T-tubule Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Metal Ion Binding	Protein Binding Ion Channel Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Osteoblast Development Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Shape Phosphorylation Cell Migration P-body Assembly Gene Silencing By MiRNA Negative Regulation Of Hippo Signaling Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Gene Silencing By MiRNA	Skeletal Muscle Contraction Signal Transduction Cellular Response To Heat Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cation Channel Activity
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30578418)	Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 29273806) Brooding (response to stress) ( 30886212) Celiac disease ( 23936387) Erectile dysfunction in type 1 diabetes ( 22704111) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 31537649) Metabolite levels ( 23823483) Smoking behaviour (maximum cigarettes in a 24 hour period) ( 29532581)
Interacting Genes		6 interacting genes: APP BRCA2 HIPK3 RPP14 STAC TRAF6	22 interacting genes: APP FBXO25 GOLGA2 KANK2 KIAA1958 LIMD1 LMNA LRRK2 LZTS2 MEOX2 NBPF19 NCKIPSD NEDD4L NOTCH2NLA PAX5 PAX6 PJA1 POU6F2 RNF208 STAT5B TRIP6 TRMO
Entrez ID		8994	6769
HPRD ID		05177	11890
Ensembl ID		ENSG00000144791	ENSG00000144681
Uniprot IDs		Q9UGP4	B4DR96 B4DZ13 E9PEA7 Q8WUK8 Q99469
PDB IDs			2DL4 6B25
Enriched GO Terms of Interacting Partners?
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